LSI 19q13 (Orange)

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Probe location


Probe description

The LSI 19q13 FISH kit is intended for the determination of the 19q13 chromosomal region deletion in human tissues using fluorescence in situ hybridization (FISH).
The LSI 19q13 FISH kit contains a directly labeled fluorescent DNA probe in hybridization buffer. The fluorochrome Orange labeled probe 19q13 covers the chromosome 19q13 region.
The 19q13 deletion together with the deletion of short arm of chromosome 1 (1p36.3) are strongly correlated with gliomas with oligodendroglial morphology. Combined deletions of 1p and 19q are found in approximately 80–90 % of grade II oligodendrogliomas and in approximately 50–70 % of anaplastic oligodendrogliomas.  Analysis of the 19q13 deletion is useful for morphological and genetic diagnostics of malignant tumors with an oligodendroglial component.

FISH results

A normal cell hybridized with the LSI 19q13 (Orange) (1a). The cell in this image shows 2 orange signals. An abnormal cell (1b) shows the one orange signal which indicates the 19q13 deletion.

A normal cell hybridized with the LSI 19q13 (Orange) shows 2 orange signals of chromosome 19q13 region. An abnormal cell hybridized with the LSI 19q13 (Orange) shows the one orange signal which indicates the loss of chromosome 19q13 region.
1a 1b

Figure1. The assessment of 19q13 status in FFPE tissue (glioma patient tissue).



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Information for use

LSI 19q13 (Orange)



upon request



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